Role of bilirubin as an antioxidant in an ischemia-reperfusion of rat liver and induction of heme oxygenase.

@article{Yamaguchi1996RoleOB,
  title={Role of bilirubin as an antioxidant in an ischemia-reperfusion of rat liver and induction of heme oxygenase.},
  author={Tokio Yamaguchi and M. Terakado and Fumihiko Horio and Kumiko Aoki and Masao Tanaka and Hiromu Nakajima},
  journal={Biochemical and biophysical research communications},
  year={1996},
  volume={223 1},
  pages={129-35}
}
The anti-oxidative effect of bilirubin was investigated in an ischemia-reperfusion model of rat liver. The rat portal vessel and liver artery were ligated with a vascular clip, and after reperfusion the urine was collected at intervals. The amount of biopyrrins, the oxidative metabolites of bilirubin, in rat urine reached a maximum 4 hours after reperfusion. Biotripyrrin-a and -b which are biopyrrins isolated from human urine were included in urinary bilirubin oxidative metabolites of rats… CONTINUE READING

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