Role of biliary phosphatidylcholine in bile acid protection and NSAID injury of the ileal mucosa in rats.


BACKGROUND & AIMS We explored the role of biliary phosphatidylcholine (PC) in protection of the intestinal mucosa against bile salt (BS)-induced intestinal injury and how this property may be blocked by indomethacin (Indo), a nonsteroidal anti-inflammatory drug (NSAID) that is secreted into the bile. METHODS We performed in vivo studies in which bile was… (More)