Role of bile acids and bile acid receptors in metabolic regulation.

  title={Role of bile acids and bile acid receptors in metabolic regulation.},
  author={Philippe Lefebvre and Bertrand Cariou and Fleur Lien and Folkert Kuipers and Bart Staels},
  journal={Physiological reviews},
  volume={89 1},
The incidence of the metabolic syndrome has taken epidemic proportions in the past decades, contributing to an increased risk of cardiovascular disease and diabetes. The metabolic syndrome can be defined as a cluster of cardiovascular disease risk factors including visceral obesity, insulin resistance, dyslipidemia, increased blood pressure, and hypercoagulability. The farnesoid X receptor (FXR) belongs to the superfamily of ligand-activated nuclear receptor transcription factors. FXR is… 

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