Role of beta-lactam hydrolysis in the mechanism of resistance of a beta-lactamase-constitutive Enterobacter cloacae strain to expanded-spectrum beta-lactams

@article{Vu1985RoleOB,
  title={Role of beta-lactam hydrolysis in the mechanism of resistance of a beta-lactamase-constitutive Enterobacter cloacae strain to expanded-spectrum beta-lactams},
  author={H K Vu and Hiroshi Nikaido},
  journal={Antimicrobial Agents and Chemotherapy},
  year={1985},
  volume={27},
  pages={393 - 398}
}
  • H. Vu, H. Nikaido
  • Published 1 March 1985
  • Chemistry, Medicine
  • Antimicrobial Agents and Chemotherapy
Enterobacter cloacae strains producing chromosomally mediated beta-lactamase constitutively show high degrees of resistance to most of the third-generation beta-lactams. It has been proposed that this resistance is due to the nonhydrolytic binding or trapping of beta-lactams by the enzyme. We found that the outer membrane of E. cloacae strain 55M indeed had permeability to cefazolin about 14-fold lower than that of Escherichia coli, and that the number of beta-lactamase molecules produced by… 
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