Role of beta 2-glycoprotein I and anti-phospholipid antibodies in activation of protein C in vitro.

Abstract

AIMS To investigate the effect of beta 2-glycoprotein I (beta 2 GPI) on the thrombin/thrombomodulin dependent activation of protein C; and to determine whether beta 2 GPI dependent anticardiolipin antibodies have any effect. METHODS Protein C was activated by thrombin in the presence of thrombomodulin and phospholipid vesicles in an in vitro system. The… (More)

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