Role of beta(3)-endonexin in the regulation of NF-kappaB-dependent expression of urokinase-type plasminogen activator receptor.

@article{Besta2002RoleOB,
  title={Role of beta(3)-endonexin in the regulation of NF-kappaB-dependent expression of urokinase-type plasminogen activator receptor.},
  author={Felicitas Besta and Steffen Massberg and Korbinian Brand and Elke M{\"u}ller and Sharon Page and Sabine Gruener and Michael Lorenz and Karin Sadoul and Waldemar Kolanus and Ernst Lengyel and Meinrad Gawaz},
  journal={Journal of cell science},
  year={2002},
  volume={115 Pt 20},
  pages={3879-88}
}
Endothelial migration on extracellular matrix is regulated by integrins and proteolysis. Previous studies showed that beta(3)-integrins regulate expression of the urokinase-type plasminogen activator receptor (uPAR) through outside-in signalling involving the cytoplasmic domain. Here we show that overexpression of the integrin-binding protein beta(3… CONTINUE READING