Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502).

@article{Salvadori2008RoleOB,
  title={Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502).},
  author={S. Salvadori and Stella Fiorini and C. Trapella and F. Porreca and P. Davis and Y. Sasaki and A. Ambo and E. Marczak and L. Lazarus and G. Balboni},
  journal={Bioorganic \& medicinal chemistry},
  year={2008},
  volume={16 6},
  pages={
          3032-8
        }
}
H-Dmt-Tic-NH-CH(2)-Bid (UFP-502) was the first delta-opioid agonist prepared from the Dmt-Tic pharmacophore. It showed interesting pharmacological properties, such as stimulation of mRNA BDNF expression and antidepression. To evaluate the importance of 1H-benzimidazol-2-yl (Bid) in the induction of delta-agonism, it was substituted by similar heterocycles: The substitution of NH(1) by O or S transforms the reference delta-agonist into delta-antagonists. Phenyl ring of benzimidazole is not… Expand
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