The active transport of free glucose and glucose released in membrane hydrolysis involves oxygenation of mucosal and seroseal surfaces as well as bilateral one. The glucose accumulation against the electrochemical gradient increases in transition from fasting to satiety. The data obtained suggest a hypothesis stating that enterocytes and, probably, other functionally polarized cells have not a single (basolateral) but double types of the cellular respiration: the apical as well as the basolateral ones. In addition to diffusion exchange of O2 and CO2 between the blood and the basolateral surface of cells, the gas exchange is supposed to occur at the apical surface as well. The O2 transport to this particular surface of cells can be based on the Na+ microcirculation. The interrelationship between the apical and basolateral types of respiration was shown to depend on the functional condition of the organism (satiety or hunger).