Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation.

  title={Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation.},
  author={Frank M Strutz and Michael Zeisberg and Fuad N. Ziyadeh and Chang-qing Yang and Raghu Kalluri and Gerhard A. M{\"u}ller and Eric G. Neilson},
  journal={Kidney international},
  volume={61 5},
BACKGROUND Epithelial-mesenchymal transformation (EMT) plays an important role in embryonic development and tumorigenesis and has been described in organ remodeling during fibrogenesis. In the kidney, EMT can be induced efficiently in cultured proximal tubular epithelium by coincubation of transforming growth factor (TGF)-beta1 and epidermal growth factor (EGF). Recently, we also have observed overexpression of basic fibroblast growth factor-2 (FGF-2) protein and mRNA in human kidneys with… CONTINUE READING
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