Role of base in palladium-catalyzed arylation of carbanions

  title={Role of base in palladium-catalyzed arylation of carbanions},
  author={Anton V. Mitin and Alexander N. Kashin and Irina P Beletskaya},
The arylation reaction of carbanions, derived from certain sulfones, cyanoacetic ester and malononitrile, with aryl bromides (using the catalytic system of Pd2dba3/3L, L=PPh3, PtBu3) as well as the reaction of the carbanions with one equivalent of 4-CF3C6H4 Pd(PPh3)2Br has been studied. These reactions proceed smoothly provided that the base stronger than the initial carbanion is present in the reaction mixture. In the absence of the above type of base the reactions do not proceed at all… CONTINUE READING