Role of bacteriocin immunity proteins in the antimicrobial sensitivity of Streptococcus mutans.

@article{MatsumotoNakano2006RoleOB,
  title={Role of bacteriocin immunity proteins in the antimicrobial sensitivity of Streptococcus mutans.},
  author={Michiyo Matsumoto-Nakano and Howard K. Kuramitsu},
  journal={Journal of bacteriology},
  year={2006},
  volume={188 23},
  pages={8095-102}
}
Bacteria utilize quorum-sensing systems to modulate environmental stress responses. The quorum-sensing system of Streptococcus mutans is mediated by the competence-stimulating peptide (CSP), whose precursor is encoded by the comC gene. A comC mutant of strain GS5 exhibited enhanced antimicrobial sensitivity to a wide variety of different agents. Since the addition of exogenous CSP did not complement this phenotype, it was determined that the increased tetracycline, penicillin, and triclosan… CONTINUE READING

Connections & Topics

Mentioned Connections BETA
MicrobicidesTherapeutic class ofTetracycline
Since the addition of exogenous CSP did not complement this phenotype , it was determined that the increased tetracycline , penicillin , and triclosan sensitivities resulted from repression of the putative bacteriocin immunity protein gene , bip , which is located immediately upstream from comC. We further demonstrated that the inactivation of bip or smbG , another bacteriocin immunity protein gene present within the smb operon in S. mutans GS5 , affected sensitivity to a variety of antimicrobial agents .
All Topics