Role of bacteria in gastric ulceration produced by indomethacin in the rat: cytoprotective action of antibiotics.

@article{Satoh1983RoleOB,
  title={Role of bacteria in gastric ulceration produced by indomethacin in the rat: cytoprotective action of antibiotics.},
  author={Hiroyuki Satoh and Paul H. Guth and Morton I. Grossman},
  journal={Gastroenterology},
  year={1983},
  volume={84 3},
  pages={483-9}
}
Indomethacin produces mucosal lesions in both the gastric antrum and small intestine in rats refed for 1 h after a 24-h fast. This study was designed to determine the role of bacteria in the formation of the antral lesions. A mixture of antibiotics (bacitracin, neomycin, and polymyxin B) prevented the antral lesions as well as intestinal lesions. The antibiotics also decreased the gastric corpus lesions induced by indomethacin in the fasted rat. Under a germ-free condition, indomethacin did not… CONTINUE READING
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