Role of axonal NaV1.6 sodium channels in action potential initiation of CA1 pyramidal neurons.

@article{Royeck2008RoleOA,
  title={Role of axonal NaV1.6 sodium channels in action potential initiation of CA1 pyramidal neurons.},
  author={Michel Royeck and Marie-Therese Horstmann and Stefan Remy and Margit Reitze and Yoel Yaari and Heinz Beck},
  journal={Journal of neurophysiology},
  year={2008},
  volume={100 4},
  pages={
          2361-80
        }
}
In many neuron types, the axon initial segment (AIS) has the lowest threshold for action potential generation. Its active properties are determined by the targeted expression of specific voltage-gated channel subunits. We show that the Na+ channel NaV1.6 displays a striking aggregation at the AIS of cortical neurons. To assess the functional role of this subunit, we used Scn8amed mice that are deficient for NaV1.6 subunits but still display prominent Na+ channel aggregation at the AIS. In CA1… CONTINUE READING
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