Role of autophagy in immunity and autoimmunity, with a special focus on systemic lupus erythematosus

  title={Role of autophagy in immunity and autoimmunity, with a special focus on systemic lupus erythematosus},
  author={M. Pierdominici and M. Vomero and C. Barbati and T. Colasanti and Angela Maselli and D. Vacirca and A. Giovannetti and W. Malorni and E. Ortona},
  journal={The FASEB Journal},
  pages={1400 - 1412}
  • M. Pierdominici, M. Vomero, +6 authors E. Ortona
  • Published 2012
  • Biology, Medicine
  • The FASEB Journal
  • Autophagy is a lysosome‐mediated catabolic process that allows cells to degrade unwanted cytoplasmic constituents and to recycle nutrients. Autophagy is also involved in innate and adaptive immune responses, playing a key role in interactions against microbes, in antigen processing for major histocompatibility complex (MHC) presentation, and in lymphocyte development, survival, and proliferation. Over recent years, perturbations in autophagy have been implicated in a number of diseases… CONTINUE READING
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