Role of autophagy in immunity and autoimmunity, with a special focus on systemic lupus erythematosus.

@article{Pierdominici2012RoleOA,
  title={Role of autophagy in immunity and autoimmunity, with a special focus on systemic lupus erythematosus.},
  author={Marina Pierdominici and Marta Vomero and Cristiana Barbati and Tania Colasanti and Angela Maselli and Davide Vacirca and Antonello Giovannetti and Walter Malorni and Elena Ortona},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2012},
  volume={26 4},
  pages={1400-12}
}
Autophagy is a lysosome-mediated catabolic process that allows cells to degrade unwanted cytoplasmic constituents and to recycle nutrients. Autophagy is also involved in innate and adaptive immune responses, playing a key role in interactions against microbes, in antigen processing for major histocompatibility complex (MHC) presentation, and in lymphocyte development, survival, and proliferation. Over recent years, perturbations in autophagy have been implicated in a number of diseases… CONTINUE READING
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