Role of autophagy in aging.

  title={Role of autophagy in aging.},
  author={Osamu Yamaguchi and Kinya Otsu},
  journal={Journal of cardiovascular pharmacology},
  volume={60 3},
Constitutive autophagy is important for the control of the quality of proteins and organelles to maintain cell function. Damaged proteins and organelles accumulate in aged organs. The level of autophagic activity decreases with aging. Autophagic activity is regulated by many factors, such as the insulin receptor-signaling pathway, the TOR pathway, Sirt1… CONTINUE READING