Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells.

@article{Castoria2004RoleOA,
  title={Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells.},
  author={Gabriella Castoria and Antimo Migliaccio and Marina Di Domenico and Maria Lombardi and Antonietta de Falco and Lilian Varricchio and Antonio Bilancio and Maria Vittoria Barone and Ferdinando Auricchio},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 17},
  pages={
          7643-53
        }
}
Expression of a dominant negative atypical protein kinase C (aPKC), PKCzeta, prevents nuclear translocation of extracellular regulated kinase 2 (ERK-2), p27 nuclear reduction, and DNA synthesis induced by estradiol in human mammary cancer-derived MCF-7 cells. aPKC action upstream of these events has been analyzed. In hormone-stimulated NIH 3T3 and Cos cells ectopically expressing human estrogen receptor alpha (hERalpha), aPKC is activated by phosphatidylinositol 3-kinase (PI 3-kinase) and, in… CONTINUE READING
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