Role of astrocytes in the clearance of excess extracellular potassium

@article{Walz2000RoleOA,
  title={Role of astrocytes in the clearance of excess extracellular potassium},
  author={W. Walz},
  journal={Neurochemistry International},
  year={2000},
  volume={36},
  pages={291-300}
}
  • W. Walz
  • Published 2000
  • Chemistry, Medicine
  • Neurochemistry International
  • The development of concepts describing potassium clearance mechanisms in the mammalian central nervous system in the last 35 years is reviewed. The pattern of excess potassium in the extracellular space is discussed as are the implications of these potassium levels for neuronal excitability. There is a systematic description of the available evidence for astrocytic involvement in situ. The three possible astrocytic potassium clearance mechanisms are introduced: spatial buffer mechanism; carrier… CONTINUE READING
    392 Citations

    Topics from this paper

    The Neuroglial Potassium Cycle during Neurotransmission: Role of Kir4.1 Channels
    • 49
    • Highly Influenced
    • PDF
    Chapter 7 – Potassium Channels
    Potassium buffering in the neurovascular unit: models and sensitivity analysis.
    • 33
    • PDF
    Interstitial ions: A key regulator of state-dependent neural activity?
    • 11
    The astrocyte biochemistry.
    • 14
    Glial K+ Clearance and Cell Swelling: Key Roles for Cotransporters and Pumps
    • 101
    Chloride/anion channels in glial cell membranes
    • 75
    Sodium dynamics in neurons and astrocytes under epileptifom conditions

    References

    SHOWING 1-10 OF 69 REFERENCES
    Independent mechanisms of potassium clearance by astrocytes in gliotic tissue
    • 46
    Mechanism of potassium uptake in neuropile glial cells in the central nervous system of the leech.
    • W. Wuttke
    • Psychology, Medicine
    • Journal of neurophysiology
    • 1990
    • 31
    Glial modulation of neural excitability mediated by extracellular pH: a hypothesis revisited.
    • B. Ransom
    • Chemistry, Medicine
    • Progress in brain research
    • 2000
    • 51
    Analysis of potassium dynamics in mammalian brain tissue.
    • 280
    • PDF
    Evidence for chloride ions as intracellular messenger substances in astrocytes.
    • 26
    • PDF
    Swelling and potassium uptake in cultured astrocytes.
    • W. Walz
    • Chemistry, Medicine
    • Canadian journal of physiology and pharmacology
    • 1987
    • 127
    A transmembrane sodium cycle in astrocytes
    • 69
    Brain Extracellular Space: Developmental Studies in Rat Optic Nerve a
    • 61
    Long-lasting Changes of Calcium Oscillations in Astrocytes
    • 110
    • PDF