Corpus ID: 13793851

Role of ascorbic acid in reduction of the incidence of the atrial fi brillation in patients under B-blocker and undergoing coronary artery bypass graft operation in early post-operative period

@inproceedings{AlshafeyRoleOA,
  title={Role of ascorbic acid in reduction of the incidence of the atrial fi brillation in patients under B-blocker and undergoing coronary artery bypass graft operation in early post-operative period},
  author={Mohammed K. Alshafey and Hany M. Elrakhawy and Moataz E. Rezk and Hani M. Moustafa}
}
Background: The study was done to project the important role of the anti-inflammatory and anti eoxidant properties of Ascorbic acid (vitamin C) in reducing the incidence of atrial fibrillation (AF) in the early post-operative period after coronary artery bypass graft operation (CABG). Methods: This prospective randomized study included 100 patients admitted to cardiothoracic surgery department, Benha University Hospital, Benha, Egypt between 2011 and 2016. Those patients scheduled for CABG… 

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SHOWING 1-10 OF 14 REFERENCES
Oral ascorbic acid in combination with beta-blockers is more effective than beta-blockers alone in the prevention of atrial fibrillation after coronary artery bypass grafting.
TLDR
It is concluded that ascorbic acid is effective, in addition to being well-tolerated and relatively safe, and can be prescribed as an adjunct to beta-blockers for the prophylaxis of post-bypass atrial fibrillation.
Effect of ascorbic acid on inflammatory markers after cardiothoracic surgery.
  • J. Colby, W. T. Chen, +4 authors C. White
  • Medicine
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
  • 2011
TLDR
Ascorbic acid did not attenuate the rise in inflammatory markers after CTS when compared with placebo and did not affect the natural course of inflammatory marker rise for C-reactive protein (CRP) concentration, white blood cell (WBC) count, or fibrinogen concentration versus placebo at any evaluated time point.
Pharmacologic Prophylaxis of Postoperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery: Beyond β‐Blockers
TLDR
It is found that sufficient evidence exists to recommend the use of amiodarone, sotalol, and possibly magnesium as monotherapy in patients unable to take β‐blockers or as add‐on therapy for the prevention of POAF.
Prophylaxis against atrial fibrillation after cardiac surgery: beneficial effect of perioperative metoprolol.
TLDR
Perioperative metoprolol but not amiodarone itself in combination with metoprool is associated with a significant reduction in postoperative AF, and further studies are indicated to confirm these preliminary findings.
Antioxidant therapy reduces oxidative and inflammatory tissue damage in patients subjected to cardiac surgery with extracorporeal circulation.
TLDR
The combined n-3 PUFA-antioxidant vitamin protocol therapy here proposed reduced the oxidative stress and inflammation biomarkers, in patients undergoing on-pump cardiac surgery.
Atrial fibrillation after cardiac surgery: incidence, risk factors, and economic burden.
TLDR
The overall incidence of POAF in the authors' center is close to 30%; 95.3% of patients were discharged in sinus rhythm and the increase in length and costs of hospitalization were significantly lower than in previous investigations.
Statins, Inflammation, Oxidative Stress, and Atrial Fibrillation
  • C. Kuo
  • Medicine
    Journal of cardiovascular electrophysiology
  • 2011
TLDR
While high-dose atorvastatin could reduce selective markers of inflammation, it did not affect systemic oxidative stress and did not prevent the recurrence of AF post-EC, and statin therapy should be considered for prevention of new-onset AF after coronary artery bypass grafting and patients with underlying heart disease, particularly heart failure.
Postoperative atrial fibrillation - what do we really know?
TLDR
Postoperative atrial fibrillation (POAF) is a common complication following cardiac surgery, occurring in 20% to 60% of patients, and the risks of anticoagulation may outweigh the benefits.
Antioxidant Vitamins in the Prevention of Atrial Fibrillation: What Is the Evidence?
TLDR
Evidence is found that antioxidant vitamins C and E, through their reactive-oxygen-species- (ROS-) scavenging effect, have shown a role in AF prevention in both animal and small clinical studies and recommendations for their use in the wider patient population are insufficient.
Ascorbate Attenuates Atrial Pacing-Induced Peroxynitrite Formation and Electrical Remodeling and Decreases the Incidence of Postoperative Atrial Fibrillation
TLDR
It is suggested that oxidative stress underlies early atrial electrophysiological remodeling and offer novel insight into the etiology and potential treatment of an enigmatic and difficult to control arrhythmia.
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