Role of ascorbate in oxidative protein folding

  title={Role of ascorbate in oxidative protein folding},
  author={G. B{\'a}nhegyi and M. Csala and A. Szarka and M. Vars{\'a}nyi and A. Benedetti and J. Mandl},
  • G. Bánhegyi, M. Csala, +3 authors J. Mandl
  • Published 2003
  • Chemistry, Medicine
  • BioFactors
  • Both in prokaryotic and eukaryotic cells, disulfide bond formation (oxidation and isomerization steps) are catalyzed exclusively in extracytoplasmic compartments. In eukaryotes, protein folding and disulfide bond formation are coupled processes that occur both co‐ and posttranslationally in the endoplasmic reticulum (ER), which is the main site of the synthesis and posttranslational modification of secretory and membrane proteins. The formation of a disulfide bond from the thiol groups of two… CONTINUE READING
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