Role of arrestins in endocytosis and signaling of alpha2-adrenergic receptor subtypes.

Abstract

We investigated the role of arrestins in the trafficking of human alpha2-adrenergic receptors (alpha2-ARs) and the effect of receptor trafficking on p42/p44 MAP kinase activation. alpha2-ARs expressed in COS-1 cells demonstrated a modest level of agonist-mediated internalization, with alpha2c > alpha2b > alpha2a. However, upon coexpression of arrestin-2… (More)

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@article{DeGraff1999RoleOA, title={Role of arrestins in endocytosis and signaling of alpha2-adrenergic receptor subtypes.}, author={Jessica L DeGraff and Anita Gagnon and Jeffrey L. Benovic and Mirko Orsini}, journal={The Journal of biological chemistry}, year={1999}, volume={274 16}, pages={11253-9} }