Role of arginine and its methylated derivatives in cancer biology and treatment

@article{Szende2001RoleOA,
  title={Role of arginine and its methylated derivatives in cancer biology and treatment},
  author={B{\'e}la Szende and Ernő Tyih{\'a}k and Lajos Tr{\'e}zl},
  journal={Cancer Cell International},
  year={2001},
  volume={1},
  pages={3 - 3}
}
Both L-arginine supplementation and deprivation influence cell proliferation. The effect of high doses on tumours is determined by the optical configuration: L-arginine is stimulatory, D-arginine inhibitory. Arginine-rich hexapeptides inhibited tumour growth. Deprivation of L-arginine from cell cultures enhanced apoptosis. The pro-apoptotic action of NO synthase inhibitors, like NG-monomethyl-L-arginine, is manifested through inhibition of the arginase pathway. NG-hydroxymethyl-L-arginines… CONTINUE READING
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