Role of arginine-56 within the structural protein VP3 of foot-and-mouth disease virus (FMDV) O1 Campos in virus virulence.

@article{Borca2012RoleOA,
  title={Role of arginine-56 within the structural protein VP3 of foot-and-mouth disease virus (FMDV) O1 Campos in virus virulence.},
  author={Manuel V Borca and Juan M. Pacheco and Lauren G. Holinka and C Castells Carrillo and Ethan J. Hartwig and Dami{\'a} Garriga and E Michael Kramer and Luis V Rodriguez and Maria Elisa Piccone},
  journal={Virology},
  year={2012},
  volume={422 1},
  pages={37-45}
}
FMDV O1 subtype undergoes antigenic variation under diverse growth conditions. Of particular interest is the amino acid variation observed at position 56 within the structural protein VP3. Selective pressures influence whether histidine (H) or arginine (R) is present at this position, ultimately influencing in vitro plaque morphology and in vivo pathogenesis in cattle. Using reverse genetics techniques, we have constructed FMDV type O1 Campos variants differing only at VP3 position 56… CONTINUE READING