Role of arginine 293 and glutamine 288 in communication between catalytic and allosteric sites in yeast ribonucleotide reductase.

@article{Ahmad2012RoleOA,
  title={Role of arginine 293 and glutamine 288 in communication between catalytic and allosteric sites in yeast ribonucleotide reductase.},
  author={Md. Faiz Ahmad and Prem Singh Kaushal and Qun Wan and Sanath Ranjan Wijerathna and Xiuxiang An and Mingxia Huang and Chris Godfrey Dealwis},
  journal={Journal of molecular biology},
  year={2012},
  volume={419 5},
  pages={315-29}
}
Ribonucleotide reductases (RRs) catalyze the rate-limiting step of de novo deoxynucleotide (dNTP) synthesis. Eukaryotic RRs consist of two proteins, RR1 (α) that contains the catalytic site and RR2 (β) that houses a diferric-tyrosyl radical essential for ribonucleoside diphosphate reduction. Biochemical analysis has been combined with isothermal titration calorimetry (ITC), X-ray crystallography and yeast genetics to elucidate the roles of two loop 2 mutations R293A and Q288A in Saccharomyces… CONTINUE READING
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