Role of arachidonic acid in the regulation of adrenocorticotropin release from rat anterior pituitary cell cultures.

@article{AbouSamra1986RoleOA,
  title={Role of arachidonic acid in the regulation of adrenocorticotropin release from rat anterior pituitary cell cultures.},
  author={Abdul Badi Abou-Samra and Kevin J. Catt and G. Romero Aguilera},
  journal={Endocrinology},
  year={1986},
  volume={119 4},
  pages={1427-31}
}
In addition to cAMP-dependent mechanisms, stimulation of pituitary ACTH secretion by various stimuli, including CRF, may involve phospholipid and arachidonic acid turnover. To determine the role of phospholipase A2 activation in corticotroph function, we studied the effect of exogenous arachidonic acid, phospholipase A2, and the phospholipase A2 activator melittin on ACTH release in cultured rat anterior pituitary cells. Incubation with 1-100 micron arachidonic acid, 0.01-1 micron melittin, 0.1… CONTINUE READING