Role of arachidonic acid-derived metabolites in the control of pulmonary arterial pressure and hypoxic pulmonary vasoconstriction in rats.

@article{Park2011RoleOA,
  title={Role of arachidonic acid-derived metabolites in the control of pulmonary arterial pressure and hypoxic pulmonary vasoconstriction in rats.},
  author={S J Park and Hae Young Yoo and Yung E. Earm and Seok - Jai Kim and Jin Kyoung Kim and Seong Deok Kim},
  journal={British journal of anaesthesia},
  year={2011},
  volume={106 1},
  pages={31-7}
}
BACKGROUND The roles of arachidonic acid (AA) metabolites in hypoxia-induced pulmonary vasoconstriction (HPV), a critical physiological mechanism that prevents ventilation/perfusion mismatch, are still incompletely understood. METHODS Pulmonary arterial pressure was measured in ventilated/perfused rat lungs. Isometric tones of rat intralobar pulmonary arteries were also measured, using a myograph. RESULTS Hypoxia (Po₂, 3%)-induced pulmonary arterial pressure increases (ΔPAP(hypox)) were… CONTINUE READING