Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat.

Abstract

To define the mechanisms involved in the evolution of diabetes in the Zucker diabetic fatty (ZDF) rat, beta-cell mass and replication rates were determined by immunochemistry, point-counting morphometry, and 6-h 5-bromo-2'-deoxyuridine (BrdU) incorporation. The beta-cell mass in 5- to 7-week-old prediabetic ZDF rats (4.3 +/- 0.06 mg) was similar to age… (More)

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@article{Pick1998RoleOA, title={Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat.}, author={Andreas Pick and J. Clark and C Kubstrup and Matteo Levisetti and W. John Pugh and Susan Bonner-Weir and Kenneth S. Polonsky}, journal={Diabetes}, year={1998}, volume={47 3}, pages={358-64} }