Role of apolipoprotein E and B gene variation in determining response of lipid, lipoprotein, and apolipoprotein levels to increased dietary cholesterol.

@article{Boerwinkle1991RoleOA,
  title={Role of apolipoprotein E and B gene variation in determining response of lipid, lipoprotein, and apolipoprotein levels to increased dietary cholesterol.},
  author={Eric Boerwinkle and Stephen Anthony Brown and Kenneth W. Rohrbach and Antonio M. Gotto and Wolfgang Patsch},
  journal={American journal of human genetics},
  year={1991},
  volume={49 6},
  pages={1145-54}
}
A large segment of the population is modifying its dietary cholesterol intake to achieve a healthier life-style. However, all individuals do not respond equally. We have investigated the effects that that two physiologically important polymorphisms in the apolipoprotein (apo) E and B genes have on the responses of plasma lipid, lipoprotein, and apolipoprotein levels to a high-cholesterol diet. Over a 6-wk period, individuals were prescribed two diets, one consisting of 300 mg dietary… CONTINUE READING

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