Role of antioxidant enzyme expression in the selective cytotoxic response of glioma cells to gamma-linolenic acid supplementation.

@article{Preuss2000RoleOA,
  title={Role of antioxidant enzyme expression in the selective cytotoxic response of glioma cells to gamma-linolenic acid supplementation.},
  author={Meredith Preuss and Geoffrey D. Girnun and Christine J. Darby and Nelson Khoo and Arthur A. Spector and Mike E. C. Robbins},
  journal={Free radical biology & medicine},
  year={2000},
  volume={28 7},
  pages={1143-56}
}
We hypothesized that the cytotoxic effect of GLA observed in glioma but not normal glial cells reflects differences in GLA metabolism and/or antioxidant enzyme levels between these cells. The PUFA content of unsupplemented glioma cells was approximately 50% of that seen in unsupplemented astrocytes. Supplementation with 20 microM GLA for 24 h led to a 230 and 22% increase in glioma and astrocyte PUFA content, respectively, such that both supplemented cell types contained similar levels of PUFA… CONTINUE READING

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