Role of antigen-presenting cells in the development and persistence of contact hypersensitivity

@article{Ptak1980RoleOA,
  title={Role of antigen-presenting cells in the development and persistence of contact hypersensitivity},
  author={Wlodzimierz Ptak and D R{\'o}źycka and Philip W. Askenase and Richard K. Gershon},
  journal={The Journal of Experimental Medicine},
  year={1980},
  volume={151},
  pages={362 - 375}
}
Three outcomes pertinent to contact sensitivity (CS) follow immunization with various forms of trinitrophenylated (TNP) substrates: (a) specific immunological unresponsiveness for CS is induced when immunization favors activation of splenic suppressor cells. This state is achieved by intravenous injection of trinitrophenyl-conjugated to various types of cells, such as peritoneal exudate cells (PEC). (b) A short-lived or evanescent form of CS is induced when immunization reduces activation of… CONTINUE READING
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