Role of antigen persistence and dose for CD4+ T-cell exhaustion and recovery.

Abstract

It is currently not understood how some chronic infections exhaust antigen-specific T cells over time and which pathogen components contribute to exhaustion. Here, we dissected the behavior of primed CD4(+) T cells exposed to persistent antigen using an inducible transgenic mouse system that allowed us to control antigen presentation as the only… (More)
DOI: 10.1073/pnas.1008437107

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