Role of antibiotic ligand in nascent peptide-dependent ribosome stalling.

@article{VzquezLaslop2011RoleOA,
  title={Role of antibiotic ligand in nascent peptide-dependent ribosome stalling.},
  author={Nora V{\'a}zquez-Laslop and Dorota Klepacki and Debbie C. Mulhearn and Haripriya Ramu and Olga P. Krasnykh and Scott G Franzblau and Alexander S Mankin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 26},
  pages={
          10496-501
        }
}
Specific nascent peptides in the ribosome exit tunnel can elicit translation arrest. Such ribosome stalling is used for regulation of expression of some bacterial and eukaryotic genes. The stalling is sensitive to additional cellular cues, most commonly the binding of specific small-molecular-weight cofactors to the ribosome. The role of cofactors in programmed translation arrest is unknown. By analyzing nascent peptide- and antibiotic-dependent ribosome stalling that controls inducible… CONTINUE READING

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The key role of a conserved and modified rRNA residue in the ribosomal response to the nascent peptide

  • N Vazquez-Laslop, H Ramu, D Klepacki, AS Mankin
  • EMBO J 29:3108–3117
  • 2010
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