Role of angiotensin-converting enzyme 1 within the median preoptic nucleus following chronic intermittent hypoxia.

@article{Faulk2017RoleOA,
  title={Role of angiotensin-converting enzyme 1 within the median preoptic nucleus following chronic intermittent hypoxia.},
  author={Katelynn E. Faulk and Brent Shell and Thekkethil Prashant Nedungadi and John T Cunningham},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2017},
  volume={312 2},
  pages={
          R245-R252
        }
}
Sustained hypertension is an important consequence of obstructive sleep apnea. An animal model of the hypoxemia associated with sleep apnea, chronic intermittent hypoxia (CIH), produces increased sympathetic nerve activity (SNA) and sustained increases in blood pressure. Many mechanisms have been implicated in the hypertension associated with CIH, including the role of ΔFosB within the median preoptic nucleus (MnPO). Also, the renin-angiotensin system (RAS) has been associated with CIH… CONTINUE READING
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