Role of angiotensin II in diabetic nephropathy.

  title={Role of angiotensin II in diabetic nephropathy.},
  author={David J. Leehey and Ashok Kumar Singh and Nahid Alavi and Rekha Singh},
  journal={Kidney international. Supplement},
Considerable evidence suggests that the intrarenal renin-angiotensin system plays an important role in diabetic nephropathy. Angiotensin-converting enzyme (ACE) inhibitors and angiotensin II (Ang II) receptor blockers (ARBs) can attenuate progressive glomerulosclerosis in disease models and can slow disease progression in humans. Because agents that interfere with Ang II action may decrease glomerular injury without altering glomerular pressures, it has been suggested that Ang II has direct… CONTINUE READING
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