Role of angiotensin II and endothelin-1 receptors in aging-related functional changes in rat cardiovascular system.

@article{Ishihata2006RoleOA,
  title={Role of angiotensin II and endothelin-1 receptors in aging-related functional changes in rat cardiovascular system.},
  author={Akira Ishihata and Yumi Katano},
  journal={Annals of the New York Academy of Sciences},
  year={2006},
  volume={1067},
  pages={173-81}
}
Angiotensin II (AII) and endothelin-1 (ET-1) are regarded as key players in the age-related changes in cardiovascular function. They are known to be involved in the pathogenesis of cardiac fibrosis and coronary vascular atherosclerosis. AII- and ET-induced vasoconstriction was augmented in coronary arteries of Langendorff-perfused heart from aged rats. In… CONTINUE READING