Role of angiotensin II AT1 receptor activation in cardiovascular diseases.

@article{Billet2008RoleOA,
  title={Role of angiotensin II AT1 receptor activation in cardiovascular diseases.},
  author={Sandrine Billet and Fr{\'e}d{\'e}rick Aguilar and Camille Baudry and Eric Clauser},
  journal={Kidney international},
  year={2008},
  volume={74 11},
  pages={
          1379-84
        }
}
Numerous clinical studies and experimental investigations using cell culture and animal models suggest that angiotensin II (AngII) via AT(1) receptor activation might induce cardiovascular hypertrophy, fibrosis and atherosclerosis resulting in vascular events such as myocardial infarction, heart failure or stroke and in end-organ damages. However, a question still remains: which part of these damages is due to a direct effect of AngII on its target tissues and which is due to AngII-induced… CONTINUE READING
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