Role of angiotensin AT(2) receptors in natriuresis: Intrarenal mechanisms and therapeutic potential.

@article{Carey2013RoleOA,
  title={Role of angiotensin AT(2) receptors in natriuresis: Intrarenal mechanisms and therapeutic potential.},
  author={R. M. Carey and Shetal H. Padia},
  journal={Clinical and experimental pharmacology & physiology},
  year={2013},
  volume={40 8},
  pages={527-34}
}
The renin-angiotensin system is a coordinated hormonal cascade critical for the regulation of blood pressure (BP) and kidney function. Angiotensin (Ang) II, the major angiotensin effector peptide, binds to two major receptors, namely AT1 and AT2 receptors. The AT1 receptors engender antinatriuresis and raise BP, whereas AT2 receptors oppose these effects, inducing natriuresis and reducing BP. There is high AT2 receptor expression in the adult kidney, especially in the proximal tubule. In AT2… CONTINUE READING
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