Role of androgen receptor and associated lysine-demethylase coregulators, LSD1 and JMJD2A, in localized and advanced human bladder cancer.

@article{Kauffman2011RoleOA,
  title={Role of androgen receptor and associated lysine-demethylase coregulators, LSD1 and JMJD2A, in localized and advanced human bladder cancer.},
  author={Eric C. Kauffman and Brian Robinson and Martin J. Downes and Leagh G Powell and Ming Ming Lee and Douglas S. Scherr and Lorraine J Gudas and Nigel P Mongan},
  journal={Molecular carcinogenesis},
  year={2011},
  volume={50 12},
  pages={931-44}
}
Bladder cancer is approximately three times more common in men as compared to women. We and others have previously investigated the contribution of androgens and the androgen receptor (AR) to bladder cancer. JMJD2A and LSD1 are recently discovered AR coregulator proteins that mediate AR-dependent transcription via recently described histone lysine-demethylation (KDM) mechanisms. We used immunohistochemistry to examine JMJD2A, LSD1, and AR expression in 72 radical cystectomy specimens, resulting… CONTINUE READING

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