Role of an archaeal PitA transporter in the copper and arsenic resistance of Metallosphaera sedula, an extreme thermoacidophile.

  title={Role of an archaeal PitA transporter in the copper and arsenic resistance of Metallosphaera sedula, an extreme thermoacidophile.},
  author={Samuel McCarthy and Chenbing Ai and Garrett H Wheaton and Rahul Tevatia and Valerie Eckrich and R. Kelly and P. Blum},
  journal={Journal of bacteriology},
  volume={196 20},
  • Samuel McCarthy, Chenbing Ai, +4 authors P. Blum
  • Published 2014
  • Biology, Medicine
  • Journal of bacteriology
  • Thermoacidophilic archaea, such as Metallosphaera sedula, are lithoautotrophs that occupy metal-rich environments. In previous studies, an M. sedula mutant lacking the primary copper efflux transporter, CopA, became copper sensitive. In contrast, the basis for supranormal copper resistance remained unclear in the spontaneous M. sedula mutant, CuR1. Here, transcriptomic analysis of copper-shocked cultures indicated that CuR1 had a unique regulatory response to metal challenge corresponding to… CONTINUE READING
    21 Citations
    Increased acid resistance of the archaeon, Metallosphaera sedula by adaptive laboratory evolution
    • 20
    Evolution of copper arsenate resistance for enhanced enargite bioleaching using the extreme thermoacidophile Metallosphaera sedula
    • 12
    Secretion and fusion of biogeochemically active archaeal membrane vesicles
    • 2
    Marine Archaeon Methanosarcina acetivorans Enhances Polyphosphate Metabolism Under Persistent Cadmium Stress
    • 3
    • PDF
    Exploring Fingerprints of the Extreme Thermoacidophile Metallosphaera sedula Grown on Synthetic Martian Regolith Materials as the Sole Energy Sources
    • 7
    • Highly Influenced
    • PDF


    Metal resistance and lithoautotrophy in the extreme thermoacidophile Metallosphaera sedula.
    • 38
    • PDF
    The Genome Sequence of the Metal-Mobilizing, Extremely Thermoacidophilic Archaeon Metallosphaera sedula Provides Insights into Bioleaching-Associated Metabolism
    • 132
    • PDF
    MarR-like transcriptional regulator involved in detoxification of aromatic compounds in Sulfolobus solfataricus.
    • 39
    • PDF