Role of an archaeal PitA transporter in the copper and arsenic resistance of Metallosphaera sedula, an extreme thermoacidophile.

@article{McCarthy2014RoleOA,
  title={Role of an archaeal PitA transporter in the copper and arsenic resistance of Metallosphaera sedula, an extreme thermoacidophile.},
  author={Samuel McCarthy and Chenbing Ai and Garrett H Wheaton and Rahul Tevatia and Valerie Eckrich and R. Kelly and P. Blum},
  journal={Journal of bacteriology},
  year={2014},
  volume={196 20},
  pages={
          3562-70
        }
}
  • Samuel McCarthy, Chenbing Ai, +4 authors P. Blum
  • Published 2014
  • Biology, Medicine
  • Journal of bacteriology
  • Thermoacidophilic archaea, such as Metallosphaera sedula, are lithoautotrophs that occupy metal-rich environments. In previous studies, an M. sedula mutant lacking the primary copper efflux transporter, CopA, became copper sensitive. In contrast, the basis for supranormal copper resistance remained unclear in the spontaneous M. sedula mutant, CuR1. Here, transcriptomic analysis of copper-shocked cultures indicated that CuR1 had a unique regulatory response to metal challenge corresponding to… CONTINUE READING
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