Role of an adenovirus E2 promoter binding factor in E1A-mediated coordinate gene control.

@article{Kovesdi1987RoleOA,
  title={Role of an adenovirus E2 promoter binding factor in E1A-mediated coordinate gene control.},
  author={Imi Kovesdi and Ronald Reichel and J. R. Nevins},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1987},
  volume={84 8},
  pages={2180-4}
}
A product of the adenovirus gene E1A is responsible for the stimulation of transcription from six viral promoters as well as at least two cellular promoters. We have detected a HeLa cell factor, termed E2 promoter binding factor (E2F), that appears to mediate the transcriptional stimulation of the viral E2 promoter. Competition experiments revealed that E2F did not recognize and bind to the E1B, E3, E4, or major late promoter sequences. Furthermore, three additional promoters stimulated by E1A… CONTINUE READING
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