Role of an Endoplasmic Reticulum Ca -Independent Phospholipase A2 in Cisplatin-Induced Renal Cell Apoptosis


It has been demonstrated recently that rabbit renal proximal tubule cells (RPTC) express a novel Ca -independent phospholipase A2 (iPLA2) whose activity localizes to the endoplasmic reticulum (ER-iPLA2) and is similar to group VIB PLA2. In this study, the expression of group VIB PLA2 was examined and the role of ER-iPLA2 in cisplatin-induced apoptosis was… (More)


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