Role of aminopeptidase N (CD13) in tumor-cell invasion and extracellular matrix degradation.

@article{Saiki1993RoleOA,
  title={Role of aminopeptidase N (CD13) in tumor-cell invasion and extracellular matrix degradation.},
  author={Ikuo Saiki and Hideji Fujii and Junya Yoneda and Fuminori Abe and Motowo Nakajima and Takashi Tsuruo and Ichiro Azuma},
  journal={International journal of cancer},
  year={1993},
  volume={54 1},
  pages={137-43}
}
We have investigated the effect of monoclonal antibodies (MAbs) specific for aminopeptidase N/CD13 on the invasion of human metastatic tumor cells into reconstituted basement membrane (Matrigel). The invasion of human metastatic tumor cells (SN12M renal-cell carcinoma, HT1080 fibrosarcoma and A375M melanoma) into Matrigel-coated filters was inhibited by an anti-CD13 MAb, WM15, in a concentration-dependent manner. However, this MAb did not have any effect on tumor-cell adhesion and migration to… CONTINUE READING

From This Paper

Topics from this paper.
92 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 92 extracted citations

Similar Papers

Loading similar papers…