Role of amino acid transporters in amino acid sensing.

@article{Taylor2014RoleOA,
  title={Role of amino acid transporters in amino acid sensing.},
  author={Peter M. Taylor},
  journal={The American journal of clinical nutrition},
  year={2014},
  volume={99 1},
  pages={223S-230S}
}
Amino acid (AA) transporters may act as sensors, as well as carriers, of tissue nutrient supplies. This review considers recent advances in our understanding of the AA-sensing functions of AA transporters in both epithelial and nonepithelial cells. These transporters mediate AA exchanges between extracellular and intracellular fluid compartments, delivering substrates to intracellular AA sensors. AA transporters on endosomal (eg, lysosomal) membranes may themselves function as intracellular AA… CONTINUE READING
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