Role of amino acid transporters in amino acid sensing.

  title={Role of amino acid transporters in amino acid sensing.},
  author={P. Taylor},
  journal={The American journal of clinical nutrition},
  volume={99 1},
  • P. Taylor
  • Published 2014
  • Biology, Medicine
  • The American journal of clinical nutrition
  • Amino acid (AA) transporters may act as sensors, as well as carriers, of tissue nutrient supplies. This review considers recent advances in our understanding of the AA-sensing functions of AA transporters in both epithelial and nonepithelial cells. These transporters mediate AA exchanges between extracellular and intracellular fluid compartments, delivering substrates to intracellular AA sensors. AA transporters on endosomal (eg, lysosomal) membranes may themselves function as intracellular AA… CONTINUE READING

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    Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy
    • 1,189
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    mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase
    • 1,121
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    Amino acid transport across mammalian intestinal and renal epithelia.
    • 641
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    CATs and HATs: the SLC7 family of amino acid transporters
    • 591
    • PDF
    Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling.
    • 238
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