Corpus ID: 14903282

Role of amino acid depletion in combined treatment of neoplastic cells with methotrexate and L-asparaginase.

@article{Chopkiewicz1975RoleOA,
  title={Role of amino acid depletion in combined treatment of neoplastic cells with methotrexate and L-asparaginase.},
  author={B. Chłopkiewicz and J. Koziorowska},
  journal={Cancer research},
  year={1975},
  volume={35 6},
  pages={
          1524-9
        }
}
  • B. Chłopkiewicz, J. Koziorowska
  • Published 1975
  • Biology, Medicine
  • Cancer research
  • The effect of pretreatment with L-asparaginase on the cytotoxicity of methotrexate (MTX) was studied in L5178Y murine leukemic cells and L-929 cells grown in vitro. The results were correlated with the effects of L-asparaginase on DNA synthesis. At low concentrations of the enzyme, pretreatment of cells enhanced the effect of MTX; at higher concentrations, it prevented the effect of MTX. Elimination of the MTX action was demonstrated also in L5178Y cells growing in the medium lacking L… CONTINUE READING

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