Role of alveolar phospholipids in bleomycin-induced pulmonary fibrosis in the rat.

@article{Pozzi1987RoleOA,
  title={Role of alveolar phospholipids in bleomycin-induced pulmonary fibrosis in the rat.},
  author={Ernesto Pozzi and Mario Salmona and P Masturzo and M Genghini and Mario Scelsi and L Spialtini and Maurizio Luisetti},
  journal={Respiration; international review of thoracic diseases},
  year={1987},
  volume={51 Suppl 1},
  pages={23-32}
}
The events leading to the onset of the experimental bleomycin-induced pulmonary fibrosis are so far unknown, though recent observations emphasize the crucial role played by lung phospholipids and by alveolar macrophages. In an attempt to verify this point, a series of studies were undertaken by treating rats (CD-COBS) with intratracheal instillation of a single dose of bleomycin (1.5 U). At the same time a group of animals was pretreated with ambroxol (which is known to be a powerful inducer of… CONTINUE READING