Role of alveolar macrophages in rapid elimination of adenovirus vectors administered to the epithelial surface of the respiratory tract.

@article{Worgall1997RoleOA,
  title={Role of alveolar macrophages in rapid elimination of adenovirus vectors administered to the epithelial surface of the respiratory tract.},
  author={Stefan Worgall and Philip L. Leopold and Gerhard Wolff and Barbara Ferris and N Van Roijen and Ronald G. Crystal},
  journal={Human gene therapy},
  year={1997},
  volume={8 14},
  pages={1675-84}
}
To evaluate the hypothesis that innate immune mechanisms play a major role in eliminating adenovirus (Ad) vectors from the lung, the fate of adenoviral genome of an Ad vector was quantified in the first 24 h after intratracheal administration of an Ad vector coding for beta-galactosidase (beta gal) to mice. Southern analysis with an Ad specific probe showed that 70% of the Ad genome was lost within 24 h, in both immunocompetent and immunodeficient animals. When alveolar macrophages were… CONTINUE READING

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