Role of alveolar macrophages in initiation and regulation of inflammation in Pseudomonas aeruginosa pneumonia.

@article{Kooguchi1998RoleOA,
  title={Role of alveolar macrophages in initiation and regulation of inflammation in Pseudomonas aeruginosa pneumonia.},
  author={Kunihiko Kooguchi and Satoru Hashimoto and Atsuko K. Kobayashi and Yoshihiro Kitamura and I Kudoh and Jeanine P. Wiener-Kronish and Teiji Sawa},
  journal={Infection and immunity},
  year={1998},
  volume={66 7},
  pages={3164-9}
}
To evaluate the role of alveolar macrophages (AMs) in acute Pseudomonas aeruginosa pneumonia in mice, AMs were depleted by aerosol inhalation of liposomes containing clodronate disodium. AM-depleted mice were then intratracheally infected with 5 x 10(5) CFU of P. aeruginosa. In addition to monitoring neutrophil recruitment and chemokine releases, lung injury was evaluated soon after infection (8 h) and at a later time (48 h). At 8 h, depletion of AMs reduced neutrophil recruitment, chemokine… CONTINUE READING

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