Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps.

  title={Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps.},
  author={Emanuel E. Strehler and David A. Zacharias},
  journal={Physiological reviews},
  volume={81 1},
Calcium pumps of the plasma membrane (also known as plasma membrane Ca(2+)-ATPases or PMCAs) are responsible for the expulsion of Ca(2+) from the cytosol of all eukaryotic cells. Together with Na(+)/Ca(2+) exchangers, they are the major plasma membrane transport system responsible for the long-term regulation of the resting intracellular Ca(2+) concentration. Like the Ca(2+) pumps of the sarco/endoplasmic reticulum (SERCAs), which pump Ca(2+) from the cytosol into the endoplasmic reticulum, the… 

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