Role of altered renal lipid metabolism in the development of renal injury induced by a high-fat diet.

@article{Kume2007RoleOA,
  title={Role of altered renal lipid metabolism in the development of renal injury induced by a high-fat diet.},
  author={Shinji Kume and Takashi Uzu and Shin-Ichi Araki and Toshiro Sugimoto and Keiji Isshiki and Masami Chin-Kanasaki and Masayoshi Sakaguchi and Naoto Kubota and Yasuo Terauchi and Takashi Kadowaki and Masakazu Haneda and Atsunori Kashiwagi and Daisuke Koya},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2007},
  volume={18 10},
  pages={2715-23}
}
Metabolic syndrome is associated with increased risk of chronic kidney disease, and the renal injury in patients with metabolic syndrome may be a result of altered renal lipid metabolism. We fed wild-type or insulin-sensitive heterozygous peroxisome proliferator-activated receptor gamma-deficient (PPARgamma(+/-)) mice a high-fat diet for 16 weeks. In wild-type mice, this diet induced core features of metabolic syndrome, subsequent renal lipid accumulation, and renal injury including… CONTINUE READING

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