Role of alpha7 nicotinic acetylcholine receptor in calcium signaling induced by prion protein interaction with stress-inducible protein 1.

@article{Beraldo2010RoleOA,
  title={Role of alpha7 nicotinic acetylcholine receptor in calcium signaling induced by prion protein interaction with stress-inducible protein 1.},
  author={Flavio H Beraldo and Camila P. Arantes and Tiago G{\'o}ss Santos and Nicolle Gilda Teixeira de Queiroz and Kirk D. Young and Rebecca Jane Rylett and Regina P Markus and Marco A M Prado and Vilma Regina Martins},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 47},
  pages={
          36542-50
        }
}
The prion protein (PrP(C)) is a conserved glycosylphosphatidylinositol-anchored cell surface protein expressed by neurons and other cells. Stress-inducible protein 1 (STI1) binds PrP(C) extracellularly, and this activated signaling complex promotes neuronal differentiation and neuroprotection via the extracellular signal-regulated kinase 1 and 2 (ERK1/2) and cAMP-dependent protein kinase 1 (PKA) pathways. However, the mechanism by which the PrP(C)-STI1 interaction transduces extracellular… CONTINUE READING

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