Role of alpha1- and alpha2-adrenoceptors in the regulation of locomotion and spatial behavior in the active place avoidance task: a dose-response study.

@article{Stuchlk2008RoleOA,
  title={Role of alpha1- and alpha2-adrenoceptors in the regulation of locomotion and spatial behavior in the active place avoidance task: a dose-response study.},
  author={Ale{\vs} Stuchl{\'i}k and Karel Vale{\vs}},
  journal={Neuroscience letters},
  year={2008},
  volume={433 3},
  pages={235-40}
}
Studies on the neurotransmitter substrate of locomotion and place navigation occupy a central position in behavioral neuroscience. Active allothetic place avoidance (AAPA) is a task, in which animals are trained to avoid a room frame defined stable sector on a continuously rotating arena. The aim of the present study was to test the effect of the blockage of alpha1- and alpha2-adrenoceptors, using specific antagonists prazosin and idazoxan, on the locomotor activity and spatial behavior in the… CONTINUE READING

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Central muscarinic blockade interferes with learning and retrieval of the active allothetic place avoidance task despite spatial pretraining

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